Viral dominance of reassortants between canine influenza H3N2 and pandemic (2009) H1N1 viruses from a naturally co-infected dog

Woonsung Na,Minjoo Yeom,Bo-Kyu Kang,Doo-Jin Kim,Eun-Jung Song,Minki Hong,Daesub Song,Jeong-Ki Kim,Kwang-Soo Lyoo,Hyoungjoon Moon

doi:10.1186/s12985-015-0343-z

Abstract

BackgroundSince avian-origin H3N2 canine influenza virus (CIV) was first identified in South Korea in 2008, the novel influenza virus has been reported in several countries in Asia. Reverse zoonotic transmission of pandemic H1N1 (2009) influenza virus (pH1N1) has been observed in a broad range of animal species. Viral dominance and characterization of the reassortants of both viruses was undertaken in the present study.FindingsHere we describe the viral dominance of 23 CIV reassortants between pH1N1 and canine H3N2 influenza viruses from a naturally co-infected dog. These results indicate that the M gene of pandemic H1N1 and the HA gene of canine H3N2 are predominant in the reassortants. Furthermore, unlike the original canine H3N2 virus, some reassortants showed high pathogenicity in mice.ConclusionsThis study suggests that continuous monitoring of influenza infection in companion animals may be necessary to investigate the potential of the emergence of novel influenza viruses.

Highlights

Since avian-origin H3N2 canine influenza virus (CIV) was first identified in South Korea in 2008, the novel influenza virus has been reported in several countries in Asia
This study suggests that continuous monitoring of influenza infection in companion animals may be necessary to investigate the potential of the emergence of novel influenza viruses
Most cases of reverse zoonoses have been reported in the pig population, the primary companion animals could be co-infected with pandemic H1N1 (2009) influenza virus (pH1N1) and canine H3N2 (cH3N2) viruses due to their ecophysiological characteristics

Summary

Introduction

Since avian-origin H3N2 canine influenza virus (CIV) was first identified in South Korea in 2008, the novel influenza virus has been reported in several countries in Asia. Conclusions: This study suggests that continuous monitoring of influenza infection in companion animals may be necessary to investigate the potential of the emergence of novel influenza viruses. Most cases of reverse zoonoses have been reported in the pig population, the primary companion animals could be co-infected with pH1N1 and cH3N2 viruses due to their ecophysiological characteristics

Results

Conclusion