Abstract
Blood and plasma viscosity are the major factors affecting blood flow and normal circulation. Whole blood viscosity is mainly affected by plasma viscosity, red blood cell deformability/aggregation and hematocrit, and other physiological factors. Thirty patients (twenty males + ten females) with age range 50–65 years, normotensive with history of cerebrovascular disorders, were selected according to the American Heart Stroke Association. Blood viscosity and other rheological parameters were measured after two-day abstinence from any medications. Dual effects of vinpocetine and pyritinol exhibit significant effects on all hemorheological parameters (P < 0.05), especially on low shear whole blood viscosity (P < 0.01), but they produced insignificant effects on total serum protein and high shear whole blood viscosity (P > 0.05). Therefore, joint effects of vinpocetine and pyritinol improve blood and plasma viscosity in patients with cerebrovascular disorders.
Highlights
Blood and plasma viscosity are the major factors affecting blood flow and normal circulation, so the whole blood viscosity is affected by plasma viscosity, red blood cell deformability, hematocrit, and other physiological factors
Blood viscosity is considerably higher in patients with cerebrovascular disorders due to higher hematocrit and development of atherosclerosis caused by hyperviscosity; unusual raise in blood viscosity was linked to progression of vascular complications; high blood viscosity correlated with infarct size and augment of the risk of mortality [3, 4]
Whole blood viscosity was regarded as acute phase marker expecting cardiac and cerebral disorders, so blood and plasma viscosity are a rapid simple test to predict the occurrences of disease and a rapid elevation of blood viscosity was connected with twofold increase in death risk [6]
Summary
Blood and plasma viscosity are the major factors affecting blood flow and normal circulation, so the whole blood viscosity is affected by plasma viscosity, red blood cell deformability, hematocrit, and other physiological factors. Increase in the blood viscosity was associated with development of multiple disorders via damaging the vascular endothelium; there is a positive correlation between blood viscosity and cerebrovascular disorders [1]. Plasma viscosity has Newtonian fluid properties and depends mainly on plasma protein, while blood viscosity has non-Newtonian fluid property and depends primarily on red cell deformability and hematocrit [2]. Blood viscosity is considerably higher in patients with cerebrovascular disorders due to higher hematocrit and development of atherosclerosis caused by hyperviscosity; unusual raise in blood viscosity was linked to progression of vascular complications; high blood viscosity correlated with infarct size and augment of the risk of mortality [3, 4]. Whole blood viscosity was regarded as acute phase marker expecting cardiac and cerebral disorders, so blood and plasma viscosity are a rapid simple test to predict the occurrences of disease and a rapid elevation of blood viscosity was connected with twofold increase in death risk [6]
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