Abstract
The long lifespan of the world’s population has been raising interest in the research for new solutions to delay the aging process. With the aim of skin aging prevention, solid lipid nanoparticles (SLNs) were developed in this work for the encapsulation of three lipophilic natural compounds extracted from vine cane—epigallocatechin gallate (EGCG), resveratrol and myricetin. The developed loaded-SLNs proved to be stable, maintaining their adequate physicochemical characteristics for 30 days. In addition, the loaded-SLNs formulations exhibited high encapsulation efficiencies and loading capacities and high intracellular antioxidant activity. The mixture of EGCG-loaded SLNs with resveratrol-loaded SLNs proved to have the highest protection against induced oxidative stress. The in vitro cytotoxicity of the loaded SLNs was also evaluated, showing that the developed formulations are biocompatible for concentrations up to 50 µg/mL and could be safe for use in cosmetics. The encapsulation of EGCG, resveratrol and myricetin in SLNs seems to be a suitable strategy for the delivery of these antioxidants to the skin, improving their bioavailability.
Highlights
IntroductionThe world’s population is becoming older, and the consequences of aging are gaining special attention
Introduction published maps and institutional affilThe world’s population is becoming older, and the consequences of aging are gaining special attention
To assess the compatibility between the lipids and the natural compounds, a lipid screening was made. These lipids were selected due to their biocompatibility with the skin since the aim of this work was to develop a formulation for cosmetic application for skin aging prevention
Summary
The world’s population is becoming older, and the consequences of aging are gaining special attention. It is believed that in 2050 the world’s population over 60 years will almost double, from 12% to 22% [1]. Skin aging occurs due to intrinsic and extrinsic factors. Intrinsic aging is primarily caused by oxidative damage induced by free radicals or reactive oxygen species (ROS) [2]. ROS react with DNA components, leading to DNA mutations that can compromise the cell viability. These mutations can induce protein aggregation and lipid peroxidation, among other harmful processes that lead to cell damage, homeostatic disruption and, premature cell aging and cell apoptosis [3]. ROS play a key role in normal cell signal transduction and cell cycling, high ROS levels can cause tissue and organ damage, being associated with the progression of several health conditions and diseases, such as inflammatory diseases [4], cancer [5], and stroke [6], among others
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