Abstract
Dear Editor, Vincristine is a vinca alkaloid derived from the periwinkle plant, Catharanthus rosea. It is widely used in the treatment of neoplastic diseases and is a potent agent in the armory for the treatment of acute lymphoblastic leukemia. Its doselimiting toxicity is neuropathy, which may include peripheral (motor/sensory), autonomic, cranial nerve neuropathies, or encephalopathy. Peripheral (paraesthesia, neuritic pain) and autonomic (constipation, urinary retention) neuropathies are well described. Cranial neuropathies are less frequently described however and can be associated with more morbidity. Cortical blindness, athetosis, ataxia and parkinsonian-like symptoms have been described and
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