Abstract
An effective and straightforward synthesis of 3-seleno functionalized indolinone (5) involving Vilsmeier reagent is presented. Likewise, a procedure to achieve lactamization of diclofenac with excellent yields by using hydrides is also ascertained. Compound 5 exhibited impressive growth inhibition in most of the cell lines in an NCI-60 panel, particularly towards resistant breast cancer cells.
Highlights
Ana Carolina Ruberte, ab Carlos Aydillo,ab Arun K
Organoselenium compounds have been broadly studied owing to their well-regarded biological activities.[1,2,3,4]
Among the multiple and complex health bene ts ascribed to organoselenium compounds, their role as chemotherapy agents is greatly-recognized.[3]
Summary
Ana Carolina Ruberte, ab Carlos Aydillo,ab Arun K. A two-steps reaction to yield the desired compound 4 via formation of the selenoamide and the subsequent methylation of the Se atom (Scheme 1, step 3).
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