Abstract
Anisoles and Pyridines undergo acetylation and formylation under non-classical Vilsmeier-Haack conditions. The reactants are grinded vigorously in a mortar for about 25 to 30 min at room temperature with a pestle. The introduction of formyl and acetyl groups under solvent free conditions is a unique, fast and efficient method which has not been reported in literature so far.
Highlights
Formyl and acetyl group can be efficiently introduced in organic substrates by Vilsmeier-Haack reaction (VHR)
Progress of the reaction was periodically monitored by thin layer chromatography
To check the generality of the reaction an array of substituted Anisoles 1b-1f and Pyridines 4b-4d are used as substrates under classical Vilsmeier Haack reaction conditions as shown in Schemes 1 and 2 respectively
Summary
Formyl and acetyl group can be efficiently introduced in organic substrates by Vilsmeier-Haack reaction (VHR). Vilsmeier-Haack reagent (0.015 moles) was added to organic substrate 1a and 4a (0.01mol) taken in a mortar and grinded with a pestle for about 25 to 30 minutes. Progress of the reaction was periodically monitored by thin layer chromatography. The reaction mixture was treated with 5% sodium thio sulphate solution, followed by addition of dichloroethane (DCE).
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