Abstract

We review uses of Tsallis statistical mechanics as a generalized-ensemble simulation algorithm in the protein folding problem. A simulation based on this algorithm performs a random walk in energy space, and it allows one not only to find the global-minimum-energy conformation but also to obtain probability distributions in canonical ensemble for a wide temperature range from only one simulation run. The folding properties of a penta peptide, Met-enkephalin, are studied by this algorithm.

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