Abstract
IntroductionVigabatrin (an antiepileptic drug) is used as the drug of choice in resistant epilepsy and infantile spasms. Ataxia, tremors and abnormal gait have been frequently reported following the use of this drug indicating an involvement of the cerebellum. Hence the present study was designed to study the histopathological effects of Vigabatrin on the cerebellum of albino rats. MethodsRats were divided into control group and experimental group. Vigabatrin was administered intraperitoneally to the experimental group in three graded doses for a period of 4 weeks. At the end of the treatment period, rats were sacrificed, brains dissected out, the cerebellum was separated and fixed. Slides were prepared for histological examination. ResultsSigns of intramyelinic oedema in the form of vacuolation were seen. Severity of the findings increased with increasing doses. DiscussionVigabatrin may be neurotoxic and should be used with caution, weighing the benefits against the risks. Tests for assessing cerebellar function should be performed during treatment with Vigabatrin and doses should be adjusted accordingly.
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