Abstract
Semaphorin-3E (Sema-3E) is a member of a large family of proteins originally identified as axon guidance cues in neural development. It is expressed in different cell types, such as immune cells, cancer cells, neural cells, and epithelial cells. Subsequently, dys-regulation of Sema-3E expression has been reported in various biological processes that range from cancers to autoimmune and allergic diseases. Recent work in our laboratories revealed a critical immunoregulatory role of Sema-3E in experimental allergic asthma. We further speculate possible immune modulatory function(s) of Sema-3E on natural killer (NK) cells.
Highlights
Semaphorins were first discovered as axon guidance molecules in the nervous system [1,2]
Class 6 semaphorins bind to Class A plexin receptors and carry out different biological activities depending on its vascular endothelial growth factor receptor (VEGF) co-receptor [13]
This review focuses on the recent advances in our understanding of the semaphorin-3E (Sema-3E) member of the family in these processes, and its emerging roles in regulating immune responses
Summary
Semaphorins were first discovered as axon guidance molecules in the nervous system [1,2] They represent a large family of proteins that are classified into eight classes (1–7 and V). The intracellular domain or cytoplasmic tail of the Plexin molecule is highly conserved and plays a crucial role in transmitting the signals following ligand binding. It contains a putative tyrosine phosphorylation sites, a GTPase-binding domain, and a segmented GTPase-activating protein (GAP) domain [14,15,16]. This review focuses on the recent advances in our understanding of the semaphorin-3E (Sema-3E) member of the family in these processes, and its emerging roles in regulating immune responses
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