Abstract
AbstractMany‐Membered and Donor‐Substituted Hydrocarbon RingsThe preparation of large rings 2 of the [2n]metacyclophane type by the Müller‐Röscheisen method is described. Yields of cyclic products, potential ligand or host character and ring size can be controlled by intra‐ and extraannular OCH3 groups. The 40‐membered macrocyclus 24 containing eight substituted benzene rings is the largest ring compound of this series isolated so far in pure form. Large substituents OR in position 2 of the starting bis(bromomethyl) compounds lead to higher ring member numbers. The new macrocyclic compounds, with the exception of the “dimer” 7, are all conformationally flexible according to 1H‐NMR spectra. X‐ray structural analyses were performed of the macrocycles 10, 13, 17, and 18; the inclusion of solvent molecules is proven.
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