Video-urodynamic Improvement of Trigonal BTX-A Injection for Patients with Poor Bladder Compliance Secondary to Spinal Cord Injury

Jiang Zhuocheng,Chen Hui,Jiang Chonghe,Jing Liu ,Yang Xh ,Tongwang Huang ,Xiao Xh ,Mao Huang ,Yang Xy ,Liu Ql ,Li Qq ,Keqin Xie

doi:10.12691/ajmcr-6-1-5

Abstract

Objective: To evaluate video-urodynamic improvement for trigonal BTX-A injection in patients with neurological poor bladder compliance. Methods: 68 consecutive inpatients with poor bladder compliance secondary to spinal cord injury(SCI) received trigonal injections of BTX-A(300U) into the bladder from June 2014 to February 2017. All were evaluated video-urodynamic outcome included detrusor leak point pressure (DLPP), bladder compliance (BC) and vesicoureteral reflux (VUR) at baseline and 12 weeks post-injection. Results: all outcomes improved significantly compared to baseline. The improvement percentage of DLPP (44.36%) and BC(77.13%). No patient developed unilateral or bilateral VUR. Conclusions: Trigone-including BTX-A injection is safe and effective as the treatment for low BC and does not induce VUR.

Highlights

The outcomes were the changes in the videourodynamic test evaluated at baseline, and at 12 weeks after injection: (1) incidence of vesicoureteral reflux (VUR); (2) detrusor leak point pressure (DLPP); (3) bladder compliance (BC)
Significant difference were present by week 12 for DLPP (51.48 cmH2O vs. 28.64 cm H2O, P < 0.001) and BC (5.16ml/cmH2O vs. 9.14 ml/cm H2O, P
Our study demonstrates that trigonal BTX-A injection does not induce VUR during the 12 week follow-up after injection

Summary

Introduction

Cite This Article: Jiang Zhuocheng, Chen Hui, Yang XH, Huang MP, Huang TH, Liu QL, Li QQ, Yang XY, Xiao XH, Liu J, Xie Keji, and Jiang Chonghe, “Video-urodynamic Improvement of Trigonal BTX-A Injection for Patients with Poor Bladder Compliance Secondary to Spinal Cord Injury.” American Journal of Medical Case Reports, vol 6, no. Keeping the DLPP within safe limits has become a primary treatment goal for SCI patients [3]. In the past ten years, intradetrusor injection of BTX-A was performed while avoiding the trigone to prevent VUR.

Results

Conclusion