Abstract
Background: To evaluate the effect between video endoscopic inguinal lymphadenectomy (VEIL) and open inguinal lymphadenectomy (OIL) for penile cancer to provide the evidence-based basis for the selection of the clinical therapy schemes.
 Methods: The related clinical controlled trial literatures on the effective comparison of VEIL and OIL were retrieved from the databases of CNKI and Wanfang database. The screening was independently performed by reviewer according to the including and excluding criteria. The related data were extracted and the meta-analysis performed by the RevMan 5.3 software.
 Results: A total of 9 trials were included. There were 335 cases of inguinal lymphadenectomies, in which 151 cases were VEIL and 184 cases were OIL. The meta-analysis results showed that there were no statistical differences between the two types of operations in terms of the operative time (WMD=28.74, 95% CI-4.12~61.60, P=0.09), but the difference between VEIL and OIL in term of intra-operative blood loss (WMD=-29.24, 95% CI–55.24~- 22.89, P<0.01), postoperative hospital stays (WMD=-3.43, 95%CI–5.07~-1.80, P<0.01), postoperative drainage time (WMD=-3.81, 95%CI–5.38~-2.23, P<0.01), surgical complications (Number of sides OR=0.53, 95% CI0.34~0.81, P<0.01; Number of cases OR=0.36, 95% CI0.24~0.54, P<0.01).
 Conclusion: VEIL has approximately the same time of operation to OIL, but has less intra-operative blood loss, hospital stay, postoperative drainage time and surgical complications.
Highlights
Traditional open inguinal lymphadenectomy (OIL) is a standard surgical procedure for penile cancer with local lymph node metastasis, but the incidence of postoperative complications is high, including wound infection, subcutaneous hematoma, flap necrosis, long-term nonunion of incision, edema of the lower extremities, and so on
The results showed that the difference of blood loss between video endoscopic inguinal lymphadenectomy (VEIL) and OIL was statistically significant (WMD=-29.24, 95% confidence interval (CI)–55.24~22.89, P
The results showed that the difference of hospital stays between VEIL and OIL was statistically significant(WMD=-3.43, 95%CI–5.07~1.80, P
Summary
Traditional open inguinal lymphadenectomy (OIL) is a standard surgical procedure for penile cancer with local lymph node metastasis, but the incidence of postoperative complications is high, including wound infection, subcutaneous hematoma, flap necrosis, long-term nonunion of incision, edema of the lower extremities, and so on. To evaluate the effect between video endoscopic inguinal lymphadenectomy (VEIL) and open inguinal lymphadenectomy (OIL) for penile cancer to provide the evidence-based basis for the selection of the clinical therapy schemes. The meta-analysis results showed that there were no statistical differences between the two types of operations in terms of the operative time(WMD=28.74, 95% CI-4.12~61.60, P=0.09), but the difference between VEIL and OIL in term of intra-operative blood loss(WMD=-29.24, 95% CI–55.24~22.89, P
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