Abstract
Introduction: Multiple subpial transections are an alternative to resection of the epileptic focus for select patients. Microradiosurgery is a developing technique, which uses submillimetric beams of radiation to treat disease. This preliminary study was designed to evaluate electroencephalography and behavioral findings following microradiosurgical transcortical transection (MTT) of a rat seizure focus. Materials and Methods: Kainic acid was used to induce a seizure focus within the left sensorimotor cortex of two rats. Before and up to 10 hours following synchrotron-generated MTT, video-EEG was recorded.
Highlights
Multiple subpial transections are an alternative to resection of the epileptic focus for select patients
More subtle electrographic ictal events remained detectable by EEG recording, the propagation of seizures was effectively disrupted. These results demonstrate the feasibility of recording VEEG before and after precise microbeam irradiation from a synchrotron source
The results show some promise that microradiosurgical transcortical transection (MTT) can limit the spread of seizures without causing clinically evident neurological damage
Summary
Multiple subpial transections are an alternative to resection of the epileptic focus for select patients. Microradiosurgery is a developing technique, which uses submillimetric beams of radiation to treat disease. This preliminary study was designed to evaluate electroencephalography and behavioral findings following microradiosurgical transcortical transection (MTT) of a rat seizure focus. Multiple subpial transections (MST) were pioneered in the 1970-1980's to address the need for a surgical approach to epileptic foci in eloquent cortex [1]. How to cite this article Anschel D, Bravin A, Bräuer-krisch E, et al (November 05, 2013) Video-EEG Analysis Following Microradiosurgical Transections of Rat Sensorimotor Cortex Seizure Focus.
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