Vicissitude of prostate biopsy status in Capital Medical University affiliated Beijing Friendship Hospital from 2008 to 2015

Abstract

Objective To analyse the detection of prostate cancer in Beijing Friendship Hospital, the morbidity of prostate cancer in different stratification and different clinical stages. Methods We retrospectively collected the patients who received transperineal ultrasound guided prostate biopsy (1 369 cases) from 2008 to 2015, and stratified by age, PSA, time of biopsy(14-needle biopsy before 2010 and 24-needle biopsy since 2010), PSAD, explored the biopsy rate in different stratification index and summarized the clinical stage of prostate cancer. Results 676 cases (44-91years old, mean age 72.9 years old) were diagnosed proatate cancer with the positive rate improving obviously after 2010. The prostate cancer detection rates in different groups with ages 0-49 years old, 50-59 years old, 60-69 years old, 70-79 years old, 80 years old and above were 5.3%(1/19), 23.9%(31/130), 40.1%(172/429), 56.0%(342/611), 72.2%(30/180); with PSA≤4 μg/L, 4.0 20.0 μg/L were 16.7%(11/66), 28.6%(113/395), 34.8%(112/322), 81.7%(276/338); with PSAD less than 0.15, more than 0.15 was 15.9%(45/283), 55.3%(267/483). The localized low risk prostate cancer detection rate were 2.3%(5/220), 2.9%(9/308), 3.1%(13/421), 6.4%(27/420). PSAD of patients with distant metastases is higher than any other stages(P<0.05), The difference was statistically significant. Conclusions The 24-core transperineal biopsy of prostate may improve the positive rate and the rate is higher in older ages and PSA levels. The localized low risk prostate cancer detection rate increases gradually. Key words: Prostate cancer; Retrospective study; Positive rate