Vibration Training Triggers Brown Adipocyte Relative Protein Expression in Rat White Adipose Tissue.

Chao Sun,Ruixia Zeng,Chang Liu,Yibo Zhang,Zhibang Song,Ge Cao

doi:10.1155/2015/919401

Abstract

Recently, vibration training is considered as a novel strategy of weight loss; however, its mechanisms are still unclear. In this study, normal or high-fat diet-induced rats were trained by whole body vibration for 8 weeks. We observed that the body weight and fat metabolism index, blood glucose, triglyceride, cholesterol, and free fatty acid in obesity rats decreased significantly compared with nonvibration group (n = 6). Although intrascapular BAT weight did not change significantly, vibration enhanced ATP reduction and increased protein level of the key molecule of brown adipose tissue (BAT), PGC-1α, and UCP1 in BAT. Interestingly, the adipocytes in retroperitoneal white adipose tissue (WAT) became smaller due to vibration exercise and had higher protein level of the key molecule of brown adipose tissue (BAT), PGC-1α, and UCP1 and inflammatory relative proteins, IL-6 and TNFα. Simultaneously, ATP content and PPARγ protein level in WAT became less in rats compared with nonvibration group. The results indicated that vibration training changed lipid metabolism in rats and promoted brown fat-like change in white adipose tissues through triggering BAT associated gene expression, inflammatory reflect, and reducing energy reserve.

Highlights

Inactive life style in China is increasingly inducing obesity and relative diseases, such as diabetes
There are no significant differences between control group and Whole body vibration (WBV) group in high-fat diet group or not normal diet group (Figure 1(a))
It indicated vibration training reduced the weight of high-fat diet-induced obese rats but not normal diet rats after 8 weeks

Summary

Introduction

Inactive life style in China is increasingly inducing obesity and relative diseases, such as diabetes. Combating the obesity and diabetes epidemic is urgently required. Due to limited efficacy or side effects, many pharmacological weight loss therapies, aiming at reducing energy intake, have been hampered. Special groups of people, who are disable to move as a result of deformity on a person or some diseases, need a novel exercise method. Whole body vibration (WBV) exercise is an emerging training method as complement to programs aimed at weight loss in overweight people. The addition of whole body vibration to both static and dynamic exercises appears to significantly increase oxygen uptake in overweight women [1]. Some research supported that vibration training may play a significant role in preventing osteoporosis and losing weight [3,4,5]

Methods

Results

Discussion

Conclusion