Abstract
THE clinical indications for the use of separated components of blood are now well established.1 Whole-blood transfusions are indicated only to augment a depleted blood volume due to acute blood loss, shock or conditions associated with intractable capillary bleeding. Secondary anemia from any cause is usually a normovolemic condition in which the administration of whole blood may impose an overload sufficient to produce circulatory failure. This is particularly true in debilitated patients or those with chronic cardiorenal disease and in infants. Separated red cells can safely be given in such cases in quantities sufficient to restore oxygen-carrying capacity without the . . .
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