Abstract
A high level of mortality caused by rabies among both humans and animals determines the importance of preventative measures to the development of the infection
Highlights
A high level of mortality caused by rabies among both humans and animals determines the importance of preventative measures to the development of the infection, where the leading role is taken by vaccines, since a successful outcome depends on the type of the vaccine used and how effective it is [1,2]
Dilution sequences of each vaccine are prepared, and IU). In both methods, according the 50% endpoints (ED50) for protection against challenge are to the protocol of vaccine trials, both single and double standard estimated by the method of Spearman-Karber
In the representation of our experiments, the modification to National Institutes of Health (NIH) test is to be made due to: a) During the traditional NIH test, which includes double immunization-the second vaccine administration is boosting, which increases the immune response to vaccines disproportionately to vaccine potency
Summary
A high level of mortality caused by rabies among both humans and animals determines the importance of preventative measures to the development of the infection, where the leading role is taken by vaccines, since a successful outcome depends on the type of the vaccine used and how effective it is [1,2]. In this regard, it becomes important to develop and use the quality evaluation of inactivated rabies vaccines. This test was developed in the USA in 1953 and is used in unmodified form till this day [5,6,7]
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