Abstract
Veterinary drugs are used to treat livestock and aquatic diseases and thus are introduced into animal-derived foods, endangering consumer health and safety. Antibiotic resistance is rapidly becoming a major worldwide problem, and there has been a steady increase in the number of pathogens that show multi-drug resistance. Illegal and excessive use of veterinary drugs in animals and aquaculture has serious adverse effects on humans and on all other environmental organisms. It is necessary to develop simple extraction methods and fast analytical methods to effectively detect veterinary drug residues in animal-derived foods. This review summarizes the application of various sample extraction techniques and detection and quantification methods for veterinary drug residues reported in the last decade (2010-2020). This review compares the advantages and disadvantages of various extraction techniques and detection methods and describes advanced methods, such as those that use electrochemical biosensors, piezoelectric biosensors, optical biosensors, and molecularly imprinted polymer biosensors. Finally, the future prospects and trends related to extraction methods, detection methods and advanced methods for the analysis of veterinary drug residues in animal-derived foods are summarized.
Highlights
Accepted: 4 March 2021Veterinary drugs are substances or mixtures used for the prevention, treatment, or diagnosis of animal diseases or for purposeful regulation of animal physiological functions [1]
The liquid-liquid extraction (LLE)-liquid chromatography (LC)-MS/MS method showed low limit of detection (LOD) and limit of quantification (LOQ) ranging from 0.008 μg/kg to 3.15 μg/kg with a correlation R2 value exceeding 0.99, and the relative standard deviations (RSDs) values obtained were less than 18%
LLE, solid-phase extraction (SPE), accelerated solvent extraction (ASE), QuEChERS, matrix solid-phase dispersion (MSPD) and other types of extraction methods are used for the determination of veterinary drug residues in animal-derived foods, as summarized in
Summary
Veterinary drugs are substances or mixtures used for the prevention, treatment, or diagnosis of animal diseases or for purposeful regulation of animal physiological functions [1]. Veterinary drugs usuenter fish, shrimp, and crabs as well as other aquatic products and rivers. The veterinary ally enter fish, shrimp, and crabs as well as other aquatic products and rivers The veteridrugs in these excretions and in rivers are absorbed by vegetables and by fruit trees. Mans drink water and eat vegetables and fruit containing veterinary drugs. Humans drink water and eat vegetables and fruit containing veterinary drugs. These re-enter the body and seriously endanger human health. To mation on veterinary drug residues in the environment and animal-derived foods in Figprotect the health and safety of consumers, the European Union (EU), United States, China, ure 1. Drugs in animal-derived foods [5,6,7]
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