Vessels arise in primate ovarian xenografts primarily from grafted ovarian tissue rather than from the mouse host, & neo-vascularization may increase with vascular endothelial growth factor (VEGF)

Abstract

OBJECTIVE: Autologous ovarian tissue banking & transplantation may preserve fertility for women undergoing gonadotoxic chemotherapy. Because of the risk of cancer transmission within the autologously transplanted ovarian tissue, xenografting may be an alternative. The objectives of this study are to define whether vessels in xenografted ovarian tissue arise from the mouse host or the transplanted ovary, and whether VEGF increases neo-vascularization.