Abstract
Cerebellar volumes were measured on structural MRI at adolescence and adulthood in 65 preterm individuals (born before 33 weeks’ gestation), and a term-born comparison group, in a study at King’s College, Great Ormond Street Hospital, and University College, London; and Seoul National University College of Medicine, Korea.
Highlights
Hippocampal volume reduction reported in children with chromosome 22qll.2 deletion syndrome is correlated with severity of cognitive impairment. (Deboer T et al Behav Brain Funct 2007;3:54)
The authors of the above report in infants recommend further MRI studies in older children to determine the role of the hippocampus in the high rate of cognitive impairment in preterm infants tested at a later age. They advocate interventions to decrease white matter damage and overuse of postnatal steroids and indomethacin in preterm infants, factors linked to smaller hippocampal volume
Cerebellar volumes were measured on structural MRI at adolescence and adulthood in 65 preterm individuals, and a term-born comparison group, in a study at King's College, Great Ormond Street Hospital, and University College, London; and Seoul National University College of Medicine, Korea
Summary
Hippocampal volume reduction reported in children with chromosome 22qll.2 deletion syndrome is correlated with severity of cognitive impairment. (Deboer T et al Behav Brain Funct 2007;3:54). Severe memory impairment is reported in a 5-year-old child with marked hippocampal atrophy after prolonged status epilepticus.
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