Very Important Publication: Iridium‐Catalyzed Intramolecular Enantioselective CH Alkylation at the C‐2 Position of N‐Alkenylindoles

Abstract

AbstractIntramolecular enantioselective alkylation of N‐alkenylindoles proceeded via CH bond cleavage at the C‐2 position in the presence of a cationic iridium catalyst with a diphosphine ligand. Aroyl groups at the C‐3 position of the indoles operated as effective directing groups, and chiral 1‐substituted‐2,3‐dihydro‐1H‐pyrrolo[1,2‐a]indoles were obtained in high yield with excellent ee.magnified image