Abstract
Maternal serum screening for Down syndrome is commonly performed in the 2nd trimester using α fetoprotein (AFP), unconjugated estriol (uE3), human chorionic gonadotropin (hCG), and inhibin A. Concentrations of each marker are combined with maternal age to calculate a patient-specific risk of fetal Down syndrome. In cases of Down syndrome, inhibin A concentration is, on average, approximately twice as high as in unaffected singleton pregnancies (1). Second trimester maternal serum inhibin A is also increased in twin pregnancies [1.99 multiples of the median (MoM) (1)] and in Turner syndrome with hydrops (3.91 MoM; (2)). Markedly increased inhibin A has been observed in pregnancies with complete hydatidiform mole [4–7 MoM; (3)]. Increased inhibin A may also be seen in nonpregnant women with ovarian cancer (4). We describe a woman having 2nd trimester serum inhibin …
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