Abstract

An efficient synthesis of spiro-oxindoles is accomplished by a one-pot three-component condensation of isatin, malononitrile or cyanoacetic ester and naphthol in the presence of L-proline as a catalyst. This method is of great value because of its shorter reaction times, high yield, and easy processing. An efficient one-pot procedure allows the synthesis of various spiro-oxindole derivatives with fused 4H-chromenes catalysed by L-proline in high yields under mild conditions.

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