Abstract
Verrucous squamous cell carcinoma is generally a less aggressive subtype of squamous cell carcinoma. It is most common among male patients, especially affecting the intraoral tissues. A 49-year-old male patient, rural worker, was referred to a dental specialty center because of a lesion located in the lower lip evolving within 2 months. Clinical examination showed a ±2-cm painless, hard-to-touch white lesion. No swollen lymph nodes were noticed. An incisional biopsy was performed, and the histopathologic examination revealed sheets of epidermoid cells with discreet pleomorphism, hyperchromasia, altered nuclear-cytoplasm ratio, and a few mitotic figures plus areas showing individual cell keratinization, keratin pearls, and intense deposition of lamellar keratin on the lesion surface, giving it a papillomatous-characteristic look. The diagnosis of verrucous squamous cell carcinoma was established. The patient was referred to oncology and is now waiting for the next phase of treatment.
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