Abstract
IntroductionVerrucous carcinoma of the external genitalia and perianal region is a rare variant of well-differentiated squamous cell carcinoma. It has been reported to have limited metastatic potential.Case presentationWe report the case of a 54 year-old Moroccan man who presented with locally advanced giant condyloma acuminatum (Buschke–Löwenstein tumor) after prolonged intervals of neglect (approximately 10 years). The disease covered his suprapubic, external genitalia and perianal region. It was locally aggressive with extensive tissue destruction. After a biopsy of the lesion, the diagnosis of verrucous carcinoma was confirmed. He initially received chemoradiotherapy, followed by extensive local excision, but he developed septic shock and died a few days later.ConclusionsThe purpose of this case report is to present a case of verrucous carcinoma arising in an extensive giant condyloma acuminatum (Buschke–Löwenstein tumor) and discuss the literature on its diagnosis and management.
Highlights
Verrucous carcinoma of the external genitalia and perianal region is a rare variant of well-differentiated squamous cell carcinoma
The purpose of this case report is to present a case of verrucous carcinoma arising in an extensive giant condyloma acuminatum (Buschke–Löwenstein tumor) and discuss the literature on its diagnosis and management
Case presentation A 54-year-old heterosexual married Moroccan man presented with a previous uncomplicated medical history
Summary
Surgical complete excision of VC is advised. Other treatment modalities such as chemotherapy or radiotherapy could be used to avoid mutilating surgical interventions. Based on our case and other published reports, chemoradiotherapy should be considered in patients with malignant transformation of GCA to downsize the tumor. Wide surgical excision with local flap reconstruction can significantly improve the quality of life. Consent Written informed consent was obtained from the patient’s next-of-kin for publication of this case report and any accompanying images. Authors’ contributions MA was the principal author and major contributor in writing the manuscript. All authors read and approved the final manuscript. Author details 1Department of Urology, University Hospital Center Hassan II, 30000 Fez, Morocco. Author details 1Department of Urology, University Hospital Center Hassan II, 30000 Fez, Morocco. 2Department of Pathology, University Hospital Center Hassan II, Fez, Morocco. 3Department of Urology, Reinier de Graaf Gasthuis, P.O. box 5011, 2600, GA Delft, The Netherlands
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