Abstract
ABSTRACT Verruciform xanthoma is a rare, benign lesion, with a papillary aspect, asymptomatic, sessile, white colored, and well-demarcated, that occurs in the gingiva and alveolar mucosa. The histopathological aspect is characterized by the presence of macrophages with foam cytoplasm (xanthoma cells) confined to the soft papillary tissue. The etiology and pathogenic mechanisms are unknown, although some hypothesis, such as local trauma or viral origin have been suggested. The aim of this article was report a clinical case of verruciform xanthoma located in the gingiva showing the clinical and histopathological aspects.
Highlights
Verruciform Xanthoma (VX) is a rare, benign, primary lesion that affects the oral mucosa that was described for the first time by Shafer in 19711
The pathogenic mechanisms reported in the literature for VX comprise inflammation, virus, local trauma, lipid metabolism disorders and immunological changes[7,12,15]
The authors reported a case of VX with clinical and histopathological characteristics typical of the lesion, adding another case to the world literature, with a view to the rarity of this lesion
Summary
Verruciform Xanthoma (VX) is a rare, benign, primary lesion that affects the oral mucosa that was described for the first time by Shafer in 19711. XV usually has a papillary or verruciform appearance, is sometimes associated with hyperkeratosis, and does not have a welldefined etiopathogenesis It affects the two sexes in equal proportions, and there are reports of predilection for one of the sexes. The affected age-range is around 50 years of age, involving the maxilla and mandible, in which the gingiva (premolar area) is the site presenting greatest incidence of VX2 It presents as a small, asymptomatic, slow-growing lesion, that is either sessile or pedunculated, and pink or whitened. VX is characterized by papillary or verrucous projections associated with the proliferation of pavimentous stratified epithelium with hyperparakeratosis and numerous foamy cells (histiocytes)[1] These cells are known as xanthoma cells and are confined within the lamina propria subjacent to the projections, and do not extend below the rete ridges[2]. The pathogenic mechanisms reported in the literature for VX comprise inflammation, virus, local trauma, lipid metabolism disorders and immunological changes[7,12,15]
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
