Abstract
The re-emergence and the recent spread of the Zika virus (ZIKV) has raised significant global concerns due to lack of information in patient diagnosis and management. Thus, in addition to gaining more basic information about ZIKV biology, appropriate interventions and management strategies are being sought to control ZIKV-associated diseases and its spread. This study's objective is to identify host cell proteins that are significantly dysregulated during ZIKV infection. SOMAScan, a novel aptamer-based assay, is used to simultaneously screen >1300 host proteins to detect ZIKV-induced host protein dysregulation at multiple time points during infection. A total of 125 Vero cell host proteins, including cytokines such as CXCL11 and CCL5, interferon stimulated gene 15, and translation initiation factors EIF5A and EIF4G2, are significantly dysregulated after ZIKV infection. Bioinformatic analyses of 77 host proteins, that are significantly dysregulated ≥1.25-fold, identify several activated biological processes, including the JAK/STAT, Tec kinase, and complement cascade pathways.
Highlights
IntroductionZIKV is an arbovirus that belongs to the family Flaviviridae
1.1.1 Historical background of ZIKVZIKV is an arbovirus that belongs to the family Flaviviridae
Host antiviral responses to ZIKV infection comprise several cellular pathways which have been cumulatively shown over the last decade
Summary
ZIKV is an arbovirus that belongs to the family Flaviviridae Other viruses in this family include the West Nile virus, Dengue virus, Japanese encephalitis virus, and Yellow Fever virus [1,2,3]. Fagbami in 1979 published a report of detection of ZIKV infection in 30% of patient sera from four communities in Oyo state, Nigeria, along with three other Flavivirus namely, Yellow Fever (50%), West Nile (46%), and Wesselsbron (59%) [9]. Patients were presenting Dengue-like symptoms with conjunctivitis. They were initially diagnosed serologically as being infected with the Dengue virus [10]. In French Polynesia, a woman with Guillain-Barré syndrome as well as influenza-like symptoms, was reported to be positive for ZIKV and negative for all four serotypes of Dengue by the test of plaque reduction neutralization [11]
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