Verification of latent forms of coronary heart disease in young hypertensive men with psychoautonomic disorders, working at chemically harmful manufacture

Abstract

Objective. To verify latent forms of coronary artery disease (CAD) in young hypertensive patients with psycho-vegetative disorders working at chemically hazardous industries. Design and methods. The study included 105 patients with concomitant cardiovascular disease, stratified into 3 groups (n = 35). Mean age was 35-45 years in groups 1 and 2, and 45-55 years – in group 3. In the second group, all surveyed worked at chemical hazardous industries. All patients underwent 24-hour monitoring of blood pressure and electrocardiogram, and ECG synchronized perfusion SPECT myocardial at rest and at pharmacological load test. The load included sodium adenosine triphosphate (ATP). Results. There were signs of hypertension progression, and a reduction in myocardial perfusion in the second group compared to the control group (group 1). Conclusions. Thus, we confirmed the opportunity to verify latent forms of CAD in young hypertensive subjects with psycho-vegetative disorders working at chemically hazardous industries with SPECT myocardial adenosine stress, and we found that latent forms of CAD manifest by an average of 5-7 years earlier in this group compared to the age-matched controls without occupational exposures.