Abstract
Abstract. Title of the paper: Comparative investigations of selected criteria of energy metabolism in skeletal muscle, plasma and lymphocytes in healthy and in piglets with congenital myofibrillar hypoplasia Carnitine contents of skeletal muscle, plasma and lymphocytes, the capacity of ATPsynthesis in muscle mitochondria and lymphocytes, and the enzyme activity of carnitine palmitoyltransferase I (CPT I) in muscle mitochondria were determined in piglets with congenital myofibrillar hypoplasia (CMH) in comparision to their clinical healthy siblings and piglets from CMH-free litters. Tendentious differences in the relation of acylcarnitine to free carnitine in healthy piglets and piglets suffering from CMH could be detected. Healthy piglets showed in tendency superiority in the ATP-production of their lymphocytes compared with diseased animals. Depending on the applied substrate, muscle mitochondria showed tendentially differences in the ATP-production between CMH-affected and healthy litters, so that a connection between CMH and the lipid metabolism, particular the β-oxidation, is supposed. Differences in the carnitine palmitoyltransferase I-activity as a possible cause for CMH could be excluded.
Published Version (
Free)
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
