Verbesserung der Hautphysiologie bei Frauen durch ein Ethinylestradiol- und Chlormadinonacetat-haltiges Kontrazeptivum

Abstract

BACKGROUND: The aim of this clinical study was to investigate the effects of the antiandrogen oral contraceptive (CMA/EE) Belara® on physiology of acne-prone facial skin in women with wish for hormonal contraception. MATERIAL AND METHODS: Forty-four healthy women aged between 18-37 years took part in this clinical open, prospective, single-centre, phase IV study during 24 weeks. Changes of skin parameters were investigated clinically and by biophysical in vivo methods at baseline, after 12 and 24 weeks. In addition the patients gave their subjective judgement about the influence of CMA/EE on their own skin at the beginning and after 24 weeks. RESULTS: The facial skin conditions of acne-prone skin quantified by a clinical sum score improved significantly after 12 and 24 weeks. Biophysical evaluations confirmed the good effect of the antiandrogen oral contraceptive (CMA/EE) on diverse skin parameters. The patients' subjective judgements confirmed the clinical and biophysical results. CONCLUSION: Intake of the antiandrogen hormonal oral contraceptive containing CMA/EE is an adequate method in women with acne-prone skin and wish for hormonal contraception.