Verbal working memory-related neural network communication in schizophrenia.

Abstract

Impaired working memory (WM) in schizophrenia is associated with reduced hemodynamic and electromagnetic activity and altered network connectivity within and between memory-associated neural networks. The present study sought to determine whether schizophrenia involves disruption of a frontal-parietal network normally supporting WM and/or involvement of another brain network. Nineteen schizophrenia patients (SZ) and 19 healthy comparison subjects (HC) participated in a cued visual-verbal Sternberg task while dense-array EEG was recorded. A pair of item arrays each consisting of 2-4 consonants was presented bilaterally for 200 ms with a prior cue signaling the hemifield of the task-relevant WM set. A central probe letter 2,000 ms later prompted a choice reaction time decision about match/mismatch with the target WM set. Group and WM load effects on time domain and time-frequency domain 11-15 Hz alpha power were assessed for the cue-to-probe time window, and posterior 11-15 Hz alpha power and frontal 4-8 Hz theta power were assessed during the retention period. Directional connectivity was estimated via Granger causality, evaluating group differences in communication. SZ showed slower responding, lower accuracy, smaller overall time-domain alpha power increase, and less load-dependent alpha power increase. Midline frontal theta power increases did not vary by group or load. Network communication in SZ was characterized by temporal-to-posterior information flow, in contrast to bidirectional temporal-posterior communication in HC. Results indicate aberrant WM network activity supporting WM in SZ that might facilitate normal load-dependent and only marginally less accurate task performance, despite generally slower responding.