Abstract
Type 2 diabetes mellitus (T2DM) is a complex and polygenic disorder with diverse complications. Veratrilla baillonii Franch (V. baillonii) has been applied in the intervention and treatment a diverse range of diseases, including diabetes. In this study, we revealed that water extracts of V. baillonii (WVBF) can ameliorate liver injury and insulin resistance in T2DM rat model. To elucidate the anti-diabetic mechanisms of WVBF, we performed liver transcriptome analysis that displayed WVBF treatment significantly suppressed many gene expressions involved in insulin resistance. Furthermore, functional experiments showed that WVBF treatment reduced the pathological damages of liver and pancreas, which may be regulated by Foxo1, Sirt1, G6pc, c-Met, Irs1, Akt1, Pik3r1. These results indicated that WVBF improves diabetic liver injury and insulin resistance in diabetic rats. Therefore, this study demonstrated WVBF could be used as a promising therapeutic agent for intervention and treatment of diabetes.
Highlights
Type 2 diabetes mellitus (T2DM) is a metabolic disorders-induced chronic illness, which cause abnormal glucose, lipid and protein metabolism (Pandey et al, 2015)
To explore the effects of WVBF on liver injury and insulin resistance in diabetic rats, a desirable T2DM model that induced by HFD and STZ was proposed and its metabolic features were measured
The oral glucose tolerance test (OGTT) and area under the curve (AUC) demonstrated that WVBF treatment improved glucose tolerance compared with mellitus control (MC) group at the end of 6 weeks (Figures 1F,G)
Summary
T2DM (type 2 diabetes mellitus) is a metabolic disorders-induced chronic illness, which cause abnormal glucose, lipid and protein metabolism (Pandey et al, 2015). As evidenced by the literature, the T2DM is characterized by progressive ß cell failure and insulin resistance (Cinti et al, 2016). An accumulating body of evidence indicated that insulin resistance can strengthen the pathological progression of multi-organ impairments, including kidney and liver in patients (Lontchi-Yimagou et al, 2013). Inflammation, together with disturbance of systemic and hepatic fat metabolism, is mainly regarded as causative factor in diabetic liver injury (Boden et al, 2005). Accumulating studies uncovered that the major molecules involved in metabolic disorder associated with T2DM include insulin signaling and related molecules (Tian et al, 2013)
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