Abstract
Verapamil-releasing transdermal delivery systems were designed and developed using different ratios of hydroxypropylmethylcellulose (HPMC) K4M, K15M, K100M. Formulations were selected on the basis of their drug-release content and release pattern. These were evaluated for in-vitro dissolution characteristics using a Cygnus' sandwich patch holder. The release followed Higuchi kinetics as its coefficient of correlation (r = 0.993–0.997; P 0.1) difference was observed. Urinary excretion data is suggested as a simpler alternative to blood level data in studying the kinetics of absorption and deriving the absorption parameter.
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