Abstract
AbstractWeanling rats with ventromedial hypothalamic (VMH) lesions retained 66% more body energy 1 to 4 weeks postsurgery than did nonlesioned control rats. The increased energy retention in VMH-lesioned rats resulted from diminished energy expenditure rather than from elevated energy intake. Numbers of Na+, K+-ATPase enzyme units in skeletal muscle and kidneys of these rats were estimated from saturable [3H]ouabain binding to particulate fractions. Skeletal muscle of VMH-lesioned rats had 36% fewer Na+, K+-ATPase enzyme units than did skeletal muscle of control rats. VMH-lesions did not affect the number of Na+, K+-ATPase enzyme units in kidneys. These results are comparable to earlier reports on Na+, K+-ATPase enzyme units in muscle and kidneys of obese (ob/ob) mice and suggest that there is an association between development of obesity and reduced number of Na+, K+-ATPase enzyme units in skeletal muscle.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.