Abstract
A bolus of indicator substance injected into a ventricle or an atrium will be diluted in a stepwise manner according to the pulsatile nature of bloodflow. Provided the indicator is dispersed immediately and uniformly in the ventricle or atrium the time course of the indicator can be predicted. Dilution curves recorded in three dog experiments demonstrate a stepwise change of the indicator concentration in the ascending aorta following a bolus injection into the left atrium. The information thus retrieved is entered into equations describing the mathematical model in order to calculate the distribution volumes of the indicator in the left atrium and ventricle.
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More From: Medical & Biological Engineering & Computing
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