Ventricular septal rupture complicating myocardial infarction: Comprehensive assessment of cardiac coronary arteries, anatomy, perfusion and function by multidetector computed tomography

Abstract

38-year-old man was referred for electrocardiogram (ECG)-gated multidetector computed tomography (MDCT) coronary angiography following detection of ventricular septal rupture (VSR) on transthoracic echocardiography 24 h after admission for an acute inferior wall myocardial infarction. He had been treated with primary angioplasty and stenting of a tight distal right coronary stenosis. Detailed, comprehensive evaluation of the VSR, myocardium and coronary arteries was performed with ECG-gated MDCT coronary angiography using a Brilliance 16-slice scanner (Philips Medical Systems, USA). MDCT coronary angiography showed a patent stent and a proximal heterogeneous plaque of borderline significance (Figure 1). The measured global left ventricular function, using the MDCT data, disclosed a mildly reduced ejection fraction of 47%. Regional functional analysis using cine films of the MDCT data depicted regional akinesis of the inferior and inferoseptal mid- and basal segments, manifesting as a marked reduction in myocardial thickening during systole (Video 1 – click here to view). Furthermore, first-pass myocardial perfusion analysis depicted a well-defined, nearly transmural enhancement defect parallel to the akinetic myocardial region (Figure 2). Further detailed analysis of the interventricular septum at end-diastole showed a full-thickness rupture in the mid-inferior septum (Figures 3A and 3B). Of note, the septal rupture occurred at the junction of the normally enhancing anterior septum and the hypoperfused, necrotic, inferior septum and inferior myocardial segments, indicating that this junction line appears to act as a locus minoris resistentiae. The VSR demonstrated near-complete lumen obliteration during peak systole (Figures 3A and 3B), suggesting that at least part of the bordering myocardium (anterior septum) was contracting and, thus, viable. Because the described VSR was small and of no hemodynamic significance, based on imaging findings, it was managed conservatively with follow-up echocardiography. There was no change during a three-month follow-up period.