Abstract
Summary: The effects of monensin (75 μg/kg, i.v.) on regional myocardial blood flow and ventricular arrhythmias were studied in 15 anesthetized dogs following ligation of the left anterior descending coronary artery (LAD). During the acute stages of ischemia (n = 7), atrial pacing at a constant rate (224 ± 8 min 1) resulted in fractionation and delay of potentials recorded from the epicardial surface of the ischemic zone which preceded the onset of ventricular tachycardia (VT). The progression of ischemic zone conduction delay and the time to appearance of ventricular arrhythmias were reproducible with repeated occlusions (173 ± 13 see). Blood flow in the subepicardium of the LAD region decreased following occlusion (174 ± 27 to 13 ± 3 ml/min/100 g). and was not significantly affected by monensin (75 μg/kg.i.v). although blood flow in the normal zone increased markedly (156 ± 16 to 519 ± 70 ml/min/100 g). In this series of experiments. monensin accelerated the progression of conduction delay in the ischemic zone and decreased the time to onset of VT (138 ± 12 sec, p
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