Abstract
Patients with chronic kidney disease (CKD) are susceptible to the occurrence of ventricular arrhythmias. The leading cause of death in dialysis patients is cardiac arrhythmias. The pathophysiology of arrhythmias in this population is complex and seems to be related to structural cardiac abnormalities caused by CKD, associated with several triggers, such as water and electrolyte disorders, hormonal conditions, arrhythmogenic drugs, and the dialysis procedure itself. Little is known about the clinical outcomes in CKD patients with asymptomatic ventricular arrhythmias. The results of treatments with anti-arrhythmic drugs and invasive devices are controversial in these patients, according to the available literature. The aim of this study was to review this often-neglected topic, which is of special importance in the CKD population.
Highlights
The association between chronic kidney disease (CKD) and high cardiovascular morbidity and mortality is well known.[1,2] Uremic cardiac disease progresses rapidly and is usually severe, following a different pattern from that of cardiac disease in the general population
According to the United States Renal Data System (USRDS), the leading cause of death among CKD patients undergoing dialysis is related to cardiac arrhythmias (Figure 1).[3]
This is a topic of particular relevance, little is known about the impact and management of ventricular arrhythmias in the CKD population
Summary
The association between chronic kidney disease (CKD) and high cardiovascular morbidity and mortality is well known.[1,2] Uremic cardiac disease progresses rapidly and is usually severe, following a different pattern from that of cardiac disease in the general population. According to the United States Renal Data System (USRDS), the leading cause of death among CKD patients undergoing dialysis is related to cardiac arrhythmias (Figure 1).[3] this is a topic of particular relevance, little is known about the impact and management of ventricular arrhythmias in the CKD population. Sustained VT is defined as VT that lasts more than 30 seconds, leads to syncope or cardiac arrest, or requires electric cardioversion or shock delivery by an implantable cardioverterdefibrillator (ICD).[4]
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