Abstract
Event Abstract Back to Event Ventral striatal volumes correlate with individuals’ regret related to pleasure rather than duty Tanja Jaeckle1*, Steven C. Williams1, Clifford I. Workman2, Karen E. Lythe2, Jennifer A. Gethin2, Allan H. Young1, Jorge Moll3 and Roland Zahn1, 2 1 Institute of Psychiatry, Psychology & Neuroscience (IoPPN), United Kingdom 2 The University of Manchester, United Kingdom 3 D’Or Institute for Research and Education (IDOR), Brazil Background: Patients with major depressive disorder (MDD) experience higher levels of regret even when their symptoms have subsided, suggesting that regret may add to their vulnerability to depression. So far, studies have focused on investigating primarily duty-related regret (i.e. guilt) and neglected to differentiate this from regret for not having engaged in pleasurable activities. Furthermore, the neuroanatomical basis of individual differences in regret is yet to be identified. Here, we tested the hypothesis that remitted MDD patients show higher levels of duty-related, but not pleasure-related regret which would be reflected in regional grey matter volume differences. Methods: We investigated grey matter volumes and proneness to pleasure- and duty-related regret on an experimental measure (the volitional action questionnaire) in healthy individuals (n=46) and patients with remitted MDD (n=82), not taking antidepressant medications. Results: Although no associations were detected with levels of guilt for not having fulfilled duties, pleasure-related regret was found to be positively correlated with grey matter volumes in the left ventral striatum. No differences in grey matter volumes were found between healthy individuals and patients with remitted MDD, but patients experienced higher levels of duty-related regret relative to pleasure-related regret. Conclusions: Individual differences in the tendency to experience regret for not having engaged in pleasure-related behaviours are reflected in left ventral striatal volume. Relatively lower orientation towards pleasure vs. duty outside of episodes may be a vulnerability factor for MDD and anhedonia. Keywords: ventral striatal volume, regret, Guilt, Major Depressive Disorder, Anhedonia Conference: ISAD LONDON 2017: Perspectives on Mood and Anxiety Disorders: Looking to the future, London, United Kingdom, 6 Jul - 7 Jul, 2017. Presentation Type: Poster Topic: Brain structure and brain function Citation: Jaeckle T, Williams SC, Workman CI, Lythe KE, Gethin JA, Young AH, Moll J and Zahn R (2019). Ventral striatal volumes correlate with individuals’ regret related to pleasure rather than duty. Front. Psychiatry. Conference Abstract: ISAD LONDON 2017: Perspectives on Mood and Anxiety Disorders: Looking to the future. doi: 10.3389/conf.fpsyt.2017.48.00007 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 26 May 2017; Published Online: 25 Jan 2019. * Correspondence: Ms. Tanja Jaeckle, Institute of Psychiatry, Psychology & Neuroscience (IoPPN), London, United Kingdom, tanja.jaeckle@kcl.ac.uk Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Tanja Jaeckle Steven C Williams Clifford I Workman Karen E Lythe Jennifer A Gethin Allan H Young Jorge Moll Roland Zahn Google Tanja Jaeckle Steven C Williams Clifford I Workman Karen E Lythe Jennifer A Gethin Allan H Young Jorge Moll Roland Zahn Google Scholar Tanja Jaeckle Steven C Williams Clifford I Workman Karen E Lythe Jennifer A Gethin Allan H Young Jorge Moll Roland Zahn PubMed Tanja Jaeckle Steven C Williams Clifford I Workman Karen E Lythe Jennifer A Gethin Allan H Young Jorge Moll Roland Zahn Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.
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