Abstract
In conscious intact cats, oxygen breathing for up to 1 h does not modify ventilation, and the ventilatory response to CO 2 in hyperoxia is not consistently decreased. However, oxygen breathing induces sustained hyperventilation in conscious cats after carotid body denervation. In anesthetized ctas, oxygen breathing provokes a hypoventillation which is transient under light anesthesis but more sustained under deeper levels of anesthesia. At all levels of anesthesia, the ventilatory response to CO 2 is decreased in hyperoxia as compared with normaxia. These results suggest that: (1) the effects of hyperoxia include a central stimulating component, seen only in conscious animals, which offsets the decreased ventilatory drive from peripheral chemoreceptors; (2) this central component is sensitive to anesthesia, thus allowing an explanation for the permanent decrease in ventilation and decrease in ventilatory response to CO 2 observed when oxygen is given during deep anesthesia; and (3) anesthesia may help to purposefully unmask factors involved in the control of breathing, but it markedly alters the normal functioning of the respiratory network.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
