Abstract
The effect of spinal anesthesia with hyperbaric tetracaine with epinephrine on resting ventilation and on ventilatory responsiveness to C02 rebreathing was studied in 10 unpremedicated patients. Resting end-tidal PCO 2 (PET co2 decreased from 37 ± 3 mmHg (mean ± SD) to 34 ± 2 mmHg after induction of spinal anesthesia ( p < 0.05). Minute ventilation (VE) and occlusion pressure (P 0.1) at PET co2 = 55 mmHg increased during spinal anesthesia from 32.0 ± 12.9 to 40.2 ± 17.0 l/min and from 5.0 ± 1.8 to 8.6 ± 4.7 cmH 2O, respectively. The magnitude of the increase in VE during spinal anesthesia correlated inversely with age. Spinal anesthesia was not associated with significant changes in vital capacity, maximal inspiratory pressure, or the slopes of the lines relating VE or PO 0.1 to PCO 2. These results show increased ventilatory responsiveness to C02 (a parallel leftward shift of the CO 2 response curve) with tetracaine spinal anesthesia.
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