Ventilatory and metabolic effects of repeated hypoxia in conscious newborn rabbits

Abstract

To estimate posthypoxia depressing effects on newborns, ventilatory and metabolic effects of repeated hypoxia were studied in 1- to 3-day-old (group 1) and 2-wk-old (group 2) conscious rabbits. In group 1 (n = 18), ventilation was measured by means of a flow plethysmograph. The barometric method was used in group 2 (n = 21). In an additional 19 pups of group 1 and 17 rabbits of group 2, oxygen consumption (VO2) and carbon dioxide production (VCO2) were measured with an open-flow method. In control animals minute ventilation (VE), respiratory rate, tidal volume, VO2, and VCO2 were recorded at 10-min intervals for approximately 100 min in room air. All variables did not change with time. Separate sets of newborns were exposed five times for 10 min to 10% O2 in N2. Each exposure was followed by 10 min of recovery in room air. VE measured during recoveries after hypoxia always returned to normal in group 1. In group 2, the normoxic VE during the last recovery was greater than the first value in hypoxia-treated rabbits (P < 0.05) and greater than the last value in control rabbits (P < 0.02). Although the VE response to hypoxia was not affected by repetitive exposures in group 2, at minute 5 of the fifth exposure the VE response was greater than that during the first trial in group 1 (P < 0.02). Repetitive exposures had no effects on metabolic response to hypoxia in all pups. Results of this study indicate that hypoxia-related central inhibition, if developed during the exposures, is reversed by 10 min of breathing room air in newborns.(ABSTRACT TRUNCATED AT 250 WORDS)