Abstract
PURPOSE: In rats, controlled mechanical ventilation (CMV) induced a profound reduction in diaphragm (DIA) muscle force-generating capacity as early as 24h, whereas in rabbits a similar decline was observed after 48h. Conflicting responses in rats and rabbits were extended to high-dose of methylprednisolone (MP). In rats, high-dose MP had a protective effect on CMV-induced DIA dysfunction (Respir Research 2010), whereas in rabbits had a deleterious effect (Muscle Nerve 2011). This study aimed to determine DIA force-generating capacity in animal model of critical-illness myopathy in which both cisatracurium (NM) and high-dose MP were administered in rats and rabbits receiving CMV for 48 h.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
