Abstract
Venous thromboembolism is not a risk factor for the development of bloodstream infections in critically ill COVID-19 patients
Highlights
We included all patients (≥18 years old) with PCR confirmed COVID19 admitted to the intensive care unit (ICU) of the teaching hospital Onze Lieve Vrouwe Gasthuis and two academic Amsterdam UMC hos pitals in Amsterdam, the Netherlands, from March 13th to April 30th
venous thromboembolism (VTE) was defined as pulmonary embolism (PE), deep venous throm bosis (DVT), superficial vein thrombosis or catheter related thrombosis
To determine whether VTE was independently associated with bloodstream infections (BSI), the propensity score was calculated to correct for the a-priori likelihood of patients developing a VTE
Summary
To determine whether VTE was independently associated with BSI, the propensity score was calculated to correct for the a-priori likelihood of patients developing a VTE. After correction for the propensity score, VTE ceased to be signifi cantly associated with BSI (Table 2), indicating that confounding vari ables of disease severity were responsible for the apparent increased prevalence of BSI in COVID-19 patients with VTE. In critically ill COVID-19 patients, the incidence of BSI as well as persistent BSI, was higher in patients with VTE than in those without VTE This association disappeared when correcting for con founding variables of disease severity. The high incidence of both BSI and VTE in critically ill COVID-19 patients appears to be the result of increased disease severity.
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