Abstract

Venous thromboembolism is not a risk factor for the development of bloodstream infections in critically ill COVID-19 patients

Highlights

  • We included all patients (≥18 years old) with PCR confirmed COVID19 admitted to the intensive care unit (ICU) of the teaching hospital Onze Lieve Vrouwe Gasthuis and two academic Amsterdam UMC hos­ pitals in Amsterdam, the Netherlands, from March 13th to April 30th

  • venous thromboembolism (VTE) was defined as pulmonary embolism (PE), deep venous throm­ bosis (DVT), superficial vein thrombosis or catheter related thrombosis

  • To determine whether VTE was independently associated with bloodstream infections (BSI), the propensity score was calculated to correct for the a-priori likelihood of patients developing a VTE

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Summary

ARTICLE INFO

To determine whether VTE was independently associated with BSI, the propensity score was calculated to correct for the a-priori likelihood of patients developing a VTE. After correction for the propensity score, VTE ceased to be signifi­ cantly associated with BSI (Table 2), indicating that confounding vari­ ables of disease severity were responsible for the apparent increased prevalence of BSI in COVID-19 patients with VTE. In critically ill COVID-19 patients, the incidence of BSI as well as persistent BSI, was higher in patients with VTE than in those without VTE This association disappeared when correcting for con­ founding variables of disease severity. The high incidence of both BSI and VTE in critically ill COVID-19 patients appears to be the result of increased disease severity.

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