Abstract
The quantification of blood rheology includes a number of errors, of which venous occlusion time and postural changes have not been studied systematically as yet. It can be shown that venous occlusion is associated with a time dependent hemoconcentration of samplus withdrawn distally from the cuff. This phenomenon is probably due to water loss from the intravascular space, while cells and macromolecules are held back. Postural changes from the vertical to the sitting or horizontal position are associated with a significant fluid shift into the intravascular space leading to hemodilution. Hemorheological variables are highly sensitive to these alterations. In order to avoid artefacts these variables need to be controlled in clinical trials. In order to ease interpretation of results the method of doing so should be described in publications.
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