Abstract
A method is described for the quantitative analysis of the physiological significance of either an increase or decrease in P50. The venous crossover PO2 (PvxO2) refers to that PO2 of the mixed venous blood on the standard oxyhaemoglobin equilibrium (OHE) curve at which the extraction of oxygen from the blood is the same for both the standard and the in vivo arterial and venous OHE conditions. A measured PvO2 which is greater than the PvxO2 indicates that the in vivo OHE conditions conferred a benefit over the standard conditions inasmuch as the same volume of oxygen was delivered to the tissues at a higher venous PO2. The method of determining the venous crossover PO2 from the measured arteriovenous difference in haemoglobin saturation of oxygen is described using a mathematical model of the oxyhaemoglobin equilibrium curve. The presence of carboxyhaemoglobin is accounted for in this analysis. Clinical examples in which the method is applied are presented.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Respiration; international review of thoracic diseases
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
