Abstract
The aim of the present study was to investigate the in vitro release properties of tiaprofenic acid (TA) from different topical vehicles. Carbopol ® 940 gel, chitosan gel, two types of emulsion-based ointment formulations (o/w and w/o) and hydrophilic petrolatum USP were prepared with 2% drug content. Drug release from all vehicles through a standard cellophane membrane was evaluated by using Franz-type diffusion cells. In vitro release study results showed that the diffusion coefficients of the drug from vehicles rank according to the following order: Carbopol ® 940 gel ( D = 3.11 × 10 –7 ± 0.54 cm 2/s) > chitosan gel ( D = 0.27 × 10 –7 ± 0.08 cm 2/s) > emulsion-based ointment (o/w) ( D = 0.18 × 10 –7 ± 0.05 cm 2/s) > emulsion-based ointment (w/o) ( D = 0.13 × 10 –7 ± 0.02 cm 2/s) > hydrophilic petrolatum USP ( D = 0.02 × 10 –7 ± 0.01 cm 2/s). Carbopol ® 940 gel base showed significantly higher drug release than other vehicles ( P < 0.001). These results indicated that Carbopol ® 940 gel base is a good candidate for the topical delivery of TA, giving significantly higher drug release than the other vehicles.
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