Abstract
The ability of Azone (1-dodecylazacycloheptan-2-one), a novel penetration enhancer, to increase the percutaneous delivery of metronidazole has been investigated, across full thickness human skin in vitro. A finite dose technique was used employing several vehicles. Azone at a concentration of 1% was found to be as effective as 5% and 10% concentrations in achieving enhanced transport of metronidazole. The presence of propylene glycol was found to be necessary for maximal enhancement, and the penetration of this compound was also found to be markedly enhanced by Azone. The delivery of metronidazole within the first 20 h of the experiments was increased about 25 times in the presence of 1% Azone. Repeated doses of the drug after a single dose of Azone indicated that the effect of Azone on the skin remains after several days.
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