Abstract

Previous studies have suggested an association between vascular endothelial growth factor A (VEGFA) rs3025039 polymorphism and biliary atresia (BA). However, this conclusion is controversial and there is no published pooled evidence of this association. This study was conducted and reported according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses. The protocol was registered with PROSPERO (International Prospective Register of Systematic Reviews). A thorough search was performed on databases including PubMed, Embase, and Chinese Biomedical Database up to August 2020. This study included 846 cases of BA and 2821 controls concerning VEGFA rs3025039 polymorphism. We selected relevant studies based on the following inclusion criteria: (1) the study design was case-control and cohort and (2) the patients carried standard clinical diagnoses of BA, etc. The exclusion criteria were as follows: (1) patients with other related diseases, (2) lack of requisite information and (3) duplicate data. The OR (odd ratio) and the corresponding 95% CI (confidence interval) were calculated to estimate the association. This study on VEGFA rs3025039 polymorphism in the Chinese population included 846 cases and 2821 controls. The results showed that there was no significant association between rs3025039 and susceptibility to BA under four genetic models. The results of the subgroup analysis were similar to the overall results. This meta-analysis shows that rs3025039 was not associated with susceptibility to BA in the Chinese population. Further validation may entail additional research. CRD42020203812.

Highlights

  • Biliary atresia (BA) is a type of progressive obliterative disorder in neonates that interferes with the function and anatomy of the intrahepatic and extrahepatic bile ducts.[1 2]

  • The results showed that there was no significant association between rs3025039 and susceptibility to biliary atresia (BA)

  • This meta-­analysis shows that rs3025039 was not associated with susceptibility to BA in the Chinese population

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Summary

Introduction

Biliary atresia (BA) is a type of progressive obliterative disorder in neonates that interferes with the function and anatomy of the intrahepatic and extrahepatic bile ducts.[1 2]. ► Previous studies supported that vascular endothelial growth factor A (VEGFA) plays an important role in the pathogenesis of BA. ► The association between the single nucleotide polymorphism(SNP) (rs3025039) in the VEGFA gene and the risk of BA is still controversial due to inconsistency among the previous studies. ► VEGFA rs3025039 polymorphism may not be associated with an elevated risk of BA in Chinese. ► This meta-­analysis did not demonstrate a definite association between rs3025039 and BA in northwestern Chinese because only one study was included in this subgroup. Previous studies have suggested an biliary atresia susceptibility in association between vascular endothelial growth factor A. Chinese population: a systematic (VEGFA) rs3025039 polymorphism and biliary atresia (BA). This conclusion is controversial and there is no published pooled evidence of this association

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